high b12 levels and autoimmune disease

76, 521525 (2006). The major clinical symptoms of ALPS result from lymphoproliferation, or the excessive production of a type of white blood cell called a lymphocyte, and autoimmune destruction of blood cells. High IgA and B12 - Autoimmune Disorders - MedHelp The age of the patients was similar in the 3 groups (Table 1). The https:// ensures that you are connecting to the What vitamin Am I lacking if my joints hurt? Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer, https://doi.org/10.1038/s41598-021-92945-y. I do have Hashimotos and have been on medication for years but had a relapse recently when all these symptoms appeared (TSH was 10). High or supraphysiological serum B12 levels without supplementation have been associated with many pathological conditions including renal failure, haematological disorders, cancer, and hepatic or autoimmune diseases. However, this would identically impact the 3 groups. Alcoholic liver disease is an example of a liver condition associated with high vitamin B12. Cancer-free survival in the 3 groups. 16, 235 (2015). Separate from kidney disease, inflammation can be another cause for elevated B-12 levels. Your homocysteine and methylmalonic acid (MMA) levels. doi: 10.7759/cureus.31936. 2022 Aug 9;17(1):310. doi: 10.1186/s13023-022-02453-z. As noted above, sometimes people are actually deficient in B-12. 2022 Nov 27;14(11):e31936. In contrast, people with ALPS often have abnormally low levels of HDL (high density lipoprotein) and total cholesterol. Results: Twenty six patients with ferritin levels between 10,000-15,000 ng/ml were identified. However, a falsely normal or high value of vitamin B12 in the blood may occur if antibodies interfere with the test. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. J. To get a true assessment of B12 . Minimally Invasive Surg. Sci. The basis of this article is to discuss some of the more serious or problematic things that could be causing your high vitamin B-12. 9. Having an excessively high or extremely low amount of vitamin B12 in your system can indicate a potential health problem; one of the diseases linked to B12 levels is a form of leukemia called chronic myelocytic leukemia. 8. 10. A low level of vitamin B12 in the blood indicates pernicious anemia. Dizziness. Cancer https://doi.org/10.1002/ijc.32033 (2019). The following general data were collected: sex, age, B12 levels, dates of B12 measurement, and death date. Metab Target Organ Damage. Vitamin B 12 and its binding proteins in hepatocellular carcinoma and chronic liver diseases. To avoid this, we included the sex of patients as a variable of adjustment in the survival model and, finally, sex did not significantly influence the occurrence of cancer at 60months. CAS In this study, characteristic of patients with serum vitamin B12 levels higher than 2500 pmol/L (high B12) were studied. Immune complexes and persistent high levels of serum vitamin B12 Thanks for the replies guys I believe the High IgA is most definately polyclonal, paraprotein was checked on a previous test and was negative and the blood cancers have been checked out by the blood specialist are are also negative. Thank you for visiting nature.com. government site. PLoS ONE 7, e45979 (2012). 2). These are typical labs that are done in a general screening called CBC and Chem panel. 49, 11 (2011). In the case of solid cancer diagnosed between T1 and T2, patients were excluded if the T2 assay was performed at more than 1month after cancer treatment initiation. Assays realized in intensive care and maternity units were excluded because of the metabolic changes observed in these patients21,22,23.

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